The widespread use of radiofrequency (RF) communication has increased the exposure of organisms to electromagneticfields, sparking a debate over the potential health effects of weak RF electromagnetic fields. While some experimental studies suggest that low-amplitude RF radiation may influence cellular metabolism or sleep patterns or even promote cancer, these claims remain controversial due to limited theoretical plausibility. Central to this debate is the radical pair mechanism (RPM), a quantum-mechanical framework proposed to mediate RF effects. Despite its role in magnetoreception and various magnetic field effects on chemical reactions, the RPM often fails to align with observations at low, nonthermal RF field strengths. This review examines these contrasting perspectives by discussing experimental findings and theoretical models that aim to explain putative biological effects of RF magnetic fields. Emphasis is placed on the challenges of reconciling theoretical predictions with empirical data, particularly in the context of weak RF exposure. Additionally, an overview of the theoretical framework used in current modeling efforts highlights the complexity of applying the RPM to biological systems and underscores the importance of critical interpretation. The goal is to clarify the state of understanding and inform future research on RPM-mediated biological effects under weak RF exposure.